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How well do these work? I'm downloading a ton of new distros to decide which one I want to run.

The reason I'm asking is I have to take C# on a Windows computer for school.

Can I get away with one of these?

C# code runs natively in Ubuntu.

The terminal and MonoDevelop (monodevelop) from the default Ubuntu repositories is maybe all you need. MonoDevelop can be installed from the default Ubuntu repositories in Ubuntu 17.10 and earlier. This link tells how to run C# programs from the terminal and in MonoDevelop: How do I install Mono for 17.10?

 Visual Studio Code will show up in Ubuntu Software application if you search for "vscode" or it can be installed from the terminal by running the command sudo snap install vscode --classic A snap in classic confinement behaves as a traditionally packaged application with full access to the system, and Visual Studio Code extensions are installed into the user's home directory.

After it is installed, Visual Studio Code requires additional configuration to get the debugging features of each programming language working. Depending on the programming language, this may require downloading a large amount of additional software into your home directory. This isn't the same as installing software through Wine, but Visual Studio Code will recommend installing a lot of the same software in Ubuntu that is installed in Windows which makes Ubuntu into what may be too much like a "hybrid" operating system experience for some users.

Visual Studio Code is a good and useful code editor for exactly the opposite reason. Visual Studio Code is a lot smaller than Microsoft Visual Studio, however many Visual Studio extensions can also be installed in Visual Studio Code by selecting View -> Extensions and then search for the extension that you want to install.

The wonderful C# is open source and cross platform now that Microsoft has released a version of .NET Core, and it's blazingly fast. To install .NET Core in Ubuntu follow these steps which are also listed below for Ubuntu 16.04. Visit the link for installation instructions for other Ubuntu versions.

Register Microsoft key and feed

To start installing .NET, you'll need to register the Microsoft
signature key and add the Microsoft Product feed. This only needs to
be done once per machine.

Open a command prompt and run the following commands:

curl https://packages.microsoft.com/keys/microsoft.asc | gpg --dearmor > microsoft.gpg
sudo mv microsoft.gpg /etc/apt/trusted.gpg.d/microsoft.gpg
sudo sh -c 'echo "deb [arch=amd64] https://packages.microsoft.com/repos/microsoft-ubuntu-xenial-prod xenial main" > /etc/apt/sources.list.d/dotnetdev.list' 

Install .NET SDK

Update the products available for installation, then install the .NET
SDK.

In your command prompt, run the following commands:

sudo apt install apt-transport-https
sudo apt update
sudo apt install dotnet-sdk-2.1.103

^{Comparison of Wine vs. PlayOnLinux vs. Crossover}

PlayOnLinux is a helper application designed to help you set up applications for Wine. Installing it on Ubuntu will require Wine to be installed (it will install Wine if it isn't already).

How well Wine works depends on the software you run with it. WineHQ is the best source for what applications run well with Wine and how to get them to work.