Especies reactivas del nitrógeno Referencias Menú de navegación«Reactive nitrogen species contribute to innate host defense against Campylobacter jejuni»22588521817433710.1128/IAI.01063-07974157810.1016/S0891-5849(98)00095-1«Free radicals in the physiological control of cell function»117736091669881710.1093/jxb/erj184

Compuestos de nitrógeno


óxido nítricoóxido nítrico sintasaNOS2macrófagoscitoquinasinterferón-gammalipopolisacáridossuperóxidoperoxinitritoespecies reactivas del oxígenocelularmetabolismo aeróbico




Las especies reactivas del nitrógeno son una familia de moléculas antimicrobianas derivadas del óxido nítrico (NO·) producido por la actividad enzimática de la óxido nítrico sintasa 2 (NOS2). NOS2 es expresada principalmente en macrófagos luego de la inducción por citoquinas y productos microbianos, particularmente interferón-gamma (IFN-γ) lipopolisacáridos (LPS).[1]​


Son producidas en animales a través de la reacción del óxido nítrico (NO·) con superóxido (O2−) para formar peroxinitrito (ONOO−).[2]​[3]​


Actúan en conjunto con las especies reactivas del oxígeno en el daño celular, provocando estrés nitrosativo.


Las especies reactivas del nitrógeno también son producidas de forma continua por las plantas como subproductos del metabolismo aeróbico o en respuesta al estrés.[4]​



Referencias



  1. ↑ Iovine, Nicole M.; Seema Pursnani, Alex Voldman, Gregory Wasserman, Martin J. Blaser and Yvette Weinrauch (marzo de 2008). «Reactive nitrogen species contribute to innate host defense against Campylobacter jejuni». Infection and Immunity 76 (3): 986-93. PMC 2258852. PMID 18174337. doi:10.1128/IAI.01063-07.  La referencia utiliza el parámetro obsoleto |coautores= (ayuda)


  2. ↑ Squadritoa, Giuseppe L.; William A. Pryor (septiembre de 1998). «Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide». Free Radical Biology and Medicine 25 (4-5): 392-403. PMID 9741578. doi:10.1016/S0891-5849(98)00095-1.  La referencia utiliza el parámetro obsoleto |coautores= (ayuda)


  3. ↑ Dröge, Wulf (enero de 2002). «Free radicals in the physiological control of cell function». Physiological Reviews 82 (1): 47-95. PMID 11773609. doi:10.1152/physrev.00018.2001 (inactivo 2009-03-16). 


  4. ↑ Pauly, Nicolas; Chiara Pucciariello, Karine Mandon, Gilles Innocenti, Alexandre Jamet, Emmanuel Baudouin, Didier Hérouart, Pierre Frendo and Alain Puppo (2006). «Reactive oxygen and nitrogen species and glutathione: key players in the legume-Rhizobium symbiosis». Journal of Experimental Botany 57 (8): 1769-76. PMID 16698817. doi:10.1093/jxb/erj184.  La referencia utiliza el parámetro obsoleto |coautores= (ayuda)








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